Hitoshi Kino's early work "Fujun Isei Kouyuu: Taisetsu na Kimi e" tells the story of a half-brother and sister who, after the death of their parents, were involved in a series of unpleasant and sometimes shocking events. Here you have "incest" (although they are not blood relatives) and bondage and even femdom in a sense, and all this diversity is fueled by some psychedelic echoes...